The Association between Placental Location in the First Trimester and Fetal Sex

Main Article Content

Fariba Mirbolouk
Maryam Mohammadi
Ehsan Kazemnejad Leili
Seyedeh Fatemeh Dalil Heirati


Background: Because advance knowledge of fetal sex can satisfy parental curiosity and allay anxiety, attempts at its determination prior to birth have a long history. There may also be reason to determine fetal sex when sex-specific genetic disorders are suspected. The aim of this study was to investigate the association between gestational sac (GS) location and fetal sex.

Materials and Methods: This cross-sectional study was conducted on 751 pregnant women. Transvaginal ultrasound was performed during 7-8 weeks of gestation for prenatal care and assessment of pregnancy sac and GS location. Age, parity, gravidity and GS location were recorded. Abdominal ultrasound was performed at 16-20 weeks of gestation to determine fetal health and sex and finally data was analyzed and compared to sex of the fetus after birth using SPSS software version 21.

Results: There was a significant relationship between GS location and fetal sex (P<0.0001). However, pregnancy outcomes (male or female) and GS location (anterior or posterior) were not significant correlated (P= 0.290). There was, on the other hand, a significant relationship between outcomes and GS location (right or left) (P<0.0001).

Conclusion: Maybe GS location could be considered as a helpful method for earlier fetal sex determination.

Sex, gestational sac location, placental location, ultrasound, fetus

Article Details

How to Cite
Mirbolouk, F., Mohammadi, M., Leili, E., & Dalil Heirati, S. (2019). The Association between Placental Location in the First Trimester and Fetal Sex. Journal of Pharmaceutical Research International, 27(5), 1-8.
Original Research Article


Gizzo S, Noventa M, Vitagliano A, Quaranta M, Di Giovanni V, Borgato S, et al. Sonographic assessment of placental location: A mere notional description or an important key to improve both pregnancy and perinatal obstetrical care? A large cohort study. International Journal of Clinical and Experimental Medicine. 2015;8(8):13056.

Hui L. Noninvasive approaches to prenatal diagnosis: Historical perspective and future directions. Prenatal Diagnosis: Springer. 2019;45-58.

Youssef A, Arcangeli T, Radico D, Contro E, Guasina F, Bellussi F, et al. Accuracy of fetal gender determination in the first trimester using three‐dimensional ultrasound. Ultrasound in Obstetrics & Gynecology. 2011;37(5):557-61.

Gelaw SM, Bisrat H. The role of ultrasound in determining fetal sex. Ethiopian Journal of Health Development. 2011;25(3):216-21.

Tachdjian G, Costa J, Frydman N, Ray P, Dû Le A, Kerbrat V, et al. Contribution of genotyping for fetal sex determination in maternal serum for preimplantation genetic diagnosis of X-linked diseases. Gynecologie, Obstetrique & Fertilite. 2003;31(12):1030-5.

Bartha J, Finning K, Soothill P. Fetal sex determination from maternal blood at 6 weeks of gestation when at risk for 21-hydroxylase deficiency. Obstetrics & Gynecology. 2003;101(5):1135-6. J4y asw`

Pinhas-Hamiel O, Zalel Y, Smith E, Mazkereth R, Aviram A, Lipitz S, et al. Prenatal diagnosis of sex differentiation disorders: The role of fetal ultrasound. The Journal of Clinical Endocrinology & Metabolism. 2002;87(10):4547-53.

Alizadeh A, Roudbari A, Heidarzadeh A, Jandaghi AB, Jamali MB. Ultrasonic measurement of common carotid intima-media thickness in type 2 diabetic and non-diabetic patients. Iranian Journal of Radiology. 2012;9(2):79.

Alizadeh A, Jandaghi AB, Zirak AK, Karimi A, Mardani-Kivi M, Rajabzadeh A. Knee sonography as a diagnostic test for medial meniscal tears in young patients. European Journal of Orthopaedic Surgery & Traumatology. 2013;23(8):927-31.

Sharami S, Faraji R, Khoramnia S, Dalile Heyrati S. Survey the reason of maternal request for prenatal ultrasound in low risk pregnancy. Journal of Guilan University of Medical Sciences. 2011;20(78):49-55.

Erdolu md, Köşüş A, Köşüş N, Dilmen G, Kafali H. Relationship between placental localisation, birth weight, umbilical Doppler parameters, and foetal sex. Turkish Journal of Medical Sciences. 2014;44(6): 1114-7.

Ewigman BG, Crane JP, Frigoletto FD, LeFevre ML, Bain RP, McNellis D, et al. Effect of prenatal ultrasound screening on perinatal outcome. New England Journal of Medicine. 1993;329(12):821-7.

Nasehi N, Afsar N, Bastani M, AleAli A, Jahanshahi M, Pipelzadeh M. Ultrasound accuracy in determination of fetal gender during 16-40 weeks of pregnancy. Jundishapur Scientific Medical Journal. 2008;7(3):346-351.

Pajkrt E, Chitty L. Prenatal gender determination and the diagnosis of genital anomalies. BJU International. 2004;93(4): 12-9.

Ismail SR. The relationship between placental location and fetal gender (Ramzi’s Method). Published on OBGYN.Net

The S, Chan L. P18. 17: The role of placental location assessment in the prediction of fetal gender. Ultrasound in Obstetrics & Gynecology. 2010;36(S1): 242-248.

Kanmaz AG, İnan AH, Beyan E, Karataşlı V, Çakır İ, Budak A, et al. Effects of fetal gender and low first trimester aneuploidy screening markers on preterm birth. Journal of Gynecology Obstetrics and Human Reproduction; 2019. (In Press)

Al-Qaraghouli M, Fang YMV. Effect of fetal sex on maternal and obstetric outcomes. Frontiers in Pediatrics. 2017;5(1):144- 149.

Meyer‐Wittkopf M, Schmidt S, Cooper SG, Sholler G. Three‐dimensional quantitative echocardiographic assessment of ventricular volume in healthy human fetuses with and in fetuses with congenital heart disease. Ultrasound in Obstetrics & Gynecology. 2001;18(s1):1-6.

Hammad HM, Elgyoum AMA, Abdelrahim A. Role of ultrasound in finding the relationship between placental location and fetal gender. Int J of Multidisciplinary and Current Research. 2016;47(2):247-63.

Kunz G, Beil D, Deininger H, Wildt L, Leyendecker G. The dynamics of rapid sperm transport through the female genital tract: Evidence from vaginal sonography of uterine peristalsis and hysterosalpingoscintigraphy. Human Reproduction. 1996;11(3):627-32.

Kavraĭskaia I, Nazarova L. Changes in hemodynamic parameters and temperature regimen in the system mother-placenta-fetus as affected by various drugs. Biulleten'eksperimental'noi Biologii i meditsiny. 1993;115(1):21-3.